Publikationen der Klinikapotheke

1.

Individualised dosing of antibiotics in ICU patients: timing, target and model selection matter.

Liebchen U, Briegel J, Brinkmann A, Frey O, Wicha SG.

Intensive Care Med. 2023 Apr;49(4):475-476. doi: 10.1007/s00134-023-06990-4. Epub 2023 Jan 31.

PMID: 36719458 Free PMC article. No abstract available.

2.

Study protocol of REpeat versus SIngle ShoT Antibiotic prophylaxis in major Abdominal Surgery (RESISTAAS I): a prospective observational study of antibiotic prophylaxis practice for patients undergoing major abdominal surgery.

Murtha-Lemekhova A, Fuchs J, Teroerde M, Rau H, Frey OR, Hornuss D, Billeter A, Klotz R, Chiriac U, Larmann J, Weigand MA, Probst P, Hoffmann K.

BMJ Open. 2022 Sep 19;12(9):e062088. doi: 10.1136/bmjopen-2022-062088.

PMID: 36123092 Free PMC article.

3.

[Therapeutic drug monitoring and individualized antibiotic dosing-Tool or toy on the intensive care unit].

Brinkmann A, Frey O.

Anaesthesiologie. 2022 Jul;71(7):493-494. doi: 10.1007/s00101-022-01174-z. Epub 2022 Jul 7.

PMID: 35925056 German. No abstract available.

4.

Ciprofloxacin in Patients Undergoing Extracorporeal Membrane Oxygenation (ECMO): A Population Pharmacokinetic Study.

Alihodzic D, Wicha SG, Frey OR, König C, Baehr M, Jarczak D, Kluge S, Langebrake C.

Pharmaceutics. 2022 Apr 29;14(5):965. doi: 10.3390/pharmaceutics14050965.

PMID: 35631551 Free PMC article.

5.

Validation and Application of an HPLC-UV Method for Routine Therapeutic Drug Monitoring of Dalbavancin.

Chiriac U, Rau H, Frey OR, Röhr AC, Klein S, Meyer AL, Morath B.

Antibiotics (Basel). 2022 Apr 19;11(5):541. doi: 10.3390/antibiotics11050541.

PMID: 35625185 Free PMC article.

6.

Population pharmacokinetics and toxicodynamics of continuously infused linezolid in critically ill patients.

Wicha SG, Mair A, Chiriac U, Frey OR, Fuchs T, Gaasch M, Hagel S, Richter DC, Roberts JA, Röhr AC, Weigand MA, Brinkmann A.

Int J Antimicrob Agents. 2022 May;59(5):106572. doi: 10.1016/j.ijantimicag.2022.106572. Epub 2022 Mar 18.

PMID: 35307562

7.

Correction to: Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial.

Hagel S, Bach F, Brenner T, Bracht H, Brinkmann A, Annecke T, Hohn A, Weigand MA, Michels G, Kluge S, Nierhaus A, Jarczak D, König C, Weismann D, Frey O, Witzke D, Müller C, Bauer M, Kiehntopf M, Neugebauer S, Lehmann T, Roberts JA, Pletz MW; TARGET Trial Investigators.

Intensive Care Med. 2022 May;48(5):646-647. doi: 10.1007/s00134-022-06668-3.

PMID: 35303118 Free PMC article. No abstract available.

8.

Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial.

Hagel S, Bach F, Brenner T, Bracht H, Brinkmann A, Annecke T, Hohn A, Weigand M, Michels G, Kluge S, Nierhaus A, Jarczak D, König C, Weismann D, Frey O, Witzke D, Müller C, Bauer M, Kiehntopf M, Neugebauer S, Lehmann T, Roberts JA, Pletz MW; TARGET Trial Investigators.

Intensive Care Med. 2022 Mar;48(3):311-321. doi: 10.1007/s00134-021-06609-6. Epub 2022 Feb 1.

PMID: 35106617 Free PMC article. Clinical Trial.

9.

Antibiotic Stewardship and Therapeutic Drug Monitoring of β-Lactam Antibiotics: Is There a Link? An Opinion Paper.

Richter DC, Heininger A, Chiriac U, Frey OR, Rau H, Fuchs T, Röhr AC, Brinkmann A, Weigand MA.

Ther Drug Monit. 2022 Feb 1;44(1):103-111. doi: 10.1097/FTD.0000000000000949.

PMID: 34857694 Review.

10.

Cerebrospinal Fluid Concentrations of Meropenem and Vancomycin in Ventriculitis Patients Obtained by TDM-Guided Continuous Infusion.

Tiede C, Chiriac U, Dubinski D, Raimann FJ, Frey OR, Röhr AC, Wieduwilt A, Eibach M, Filmann N, Senft C, Zacharowski K, Seifert V, Mersmann J.

Antibiotics (Basel). 2021 Nov 20;10(11):1421. doi: 10.3390/antibiotics10111421.

PMID: 34827359 Free PMC article.

11.

Excessive unbound cefazolin concentrations in critically ill patients receiving veno-arterial extracorporeal membrane oxygenation (vaECMO): an observational study.

Booke H, Frey OR, Röhr AC, Chiriac U, Zacharowski K, Holubec T, Adam EH.

Sci Rep. 2021 Aug 20;11(1):16981. doi: 10.1038/s41598-021-96654-4.

PMID: 34417526 Free PMC article.

12.

Personalized Piperacillin Dosing for the Critically Ill: A Retrospective Analysis of Clinical Experience with Dosing Software and Therapeutic Drug Monitoring to Optimize Antimicrobial Dosing.

Chiriac U, Richter DC, Frey OR, Röhr AC, Helbig S, Preisenberger J, Hagel S, Roberts JA, Weigand MA, Brinkmann A.

Antibiotics (Basel). 2021 Jun 3;10(6):667. doi: 10.3390/antibiotics10060667.

PMID: 34205135 Free PMC article.

13.

Liver function, quantified by the LiMAx test, as a predictor for the clinical outcome of critically ill patients treated with linezolid.

Alraish R, Wicha SG, Frey OR, Roehr AC, Pratschke J, Stockmann M, Wuensch T, Kaffarnik M.

Technol Health Care. 2022;30(2):309-321. doi: 10.3233/THC-191847.

PMID: 34180433

14.

Personalized ß-lactam dosing in patients with coronavirus disease 2019 (COVID-19) and pneumonia: A retrospective analysis on pharmacokinetics and pharmacokinetic target attainment.

Chiriac U, Frey OR, Roehr AC, Koeberer A, Gronau P, Fuchs T, Roberts JA, Brinkmann A.

Medicine (Baltimore). 2021 Jun 4;100(22):e26253. doi: 10.1097/MD.0000000000026253.

PMID: 34087915 Free PMC article.

15.

Cefiderocol in Critically Ill Patients with Multi-Drug Resistant Pathogens: Real-Life Data on Pharmacokinetics and Microbiological Surveillance.

König C, Both A, Rohde H, Kluge S, Frey OR, Röhr AC, Wichmann D.

Antibiotics (Basel). 2021 May 28;10(6):649. doi: 10.3390/antibiotics10060649.

PMID: 34071700 Free PMC article.

16.

Validation and Application of an HPLC-UV Method for Routine Therapeutic Drug Monitoring of Cefiderocol.

Zimmer J, Röhr AC, Kluge S, Faller J, Frey OR, Wichmann D, König C.

Antibiotics (Basel). 2021 Feb 28;10(3):242. doi: 10.3390/antibiotics10030242.

PMID: 33670891 Free PMC article.

17.

Comparison of two empirical prolonged infusion dosing regimens for meropenem in patients with septic shock: A two-center pilot study.

Eisert A, Lanckohr C, Frey J, Frey O, Wicha SG, Horn D, Ellger B, Schuerholz T, Marx G, Simon TP.

Int J Antimicrob Agents. 2021 Mar;57(3):106289. doi: 10.1016/j.ijantimicag.2021.106289. Epub 2021 Jan 27.

PMID: 33515688

18.

Pharmacokinetics of tigecycline in critically ill patients with liver failure defined by maximal liver function capacity test (LiMAx).

Alraish R, Wicha SG, Frey OR, Roehr AC, Pratschke J, Stockmann M, Wuensch T, Kaffarnik M.

Ann Intensive Care. 2020 Aug 4;10(1):106. doi: 10.1186/s13613-020-00707-2.

PMID: 32754775 Free PMC article.

19.

What Are the Predictors for Achieving Therapeutic Levetiracetam Serum Concentrations in Adult Neurological Patients?

Cotta MO, Abdul-Aziz MH, Frey OR, Sime FB, Roberts JA, Roehr AC.

Ther Drug Monit. 2020 Aug;42(4):626-630. doi: 10.1097/FTD.0000000000000731.

PMID: 31977751

20.

Therapeutic drug monitoring-guided continuous infusion of piperacillin/tazobactam significantly improves pharmacokinetic target attainment in critically ill patients: a retrospective analysis of four years of clinical experience.

Richter DC, Frey O, Röhr A, Roberts JA, Köberer A, Fuchs T, Papadimas N, Heinzel-Gutenbrunner M, Brenner T, Lichtenstern C, Weigand MA, Brinkmann A.

Infection. 2019 Dec;47(6):1001-1011. doi: 10.1007/s15010-019-01352-z. Epub 2019 Aug 31.

PMID: 31473974

21.

Therapeutic drug monitoring-based dose optimisation of piperacillin/tazobactam to improve outcome in patients with sepsis (TARGET): a prospective, multi-centre, randomised controlled trial.

Hagel S, Fiedler S, Hohn A, Brinkmann A, Frey OR, Hoyer H, Schlattmann P, Kiehntopf M, Roberts JA, Pletz MW; TARGET Study Group.

Trials. 2019 Jun 6;20(1):330. doi: 10.1186/s13063-019-3437-x.

PMID: 31171029 Free PMC article.

22.

CSF penetration of vancomycin in critical care patients with proven or suspected ventriculitis: a prospective observational study.

Blassmann U, Hope W, Roehr AC, Frey OR, Vetter-Kerkhoff C, Thon N, Briegel J, Huge V.

J Antimicrob Chemother. 2019 Apr 1;74(4):991-996. doi: 10.1093/jac/dky543.

PMID: 30689877

23.

In vitro removal of anti-infective agents by a novel cytokine adsorbent system.

König C, Röhr AC, Frey OR, Brinkmann A, Roberts JA, Wichmann D, Braune S, Kluge S, Nierhaus A.

Int J Artif Organs. 2019 Feb;42(2):57-64. doi: 10.1177/0391398818812601. Epub 2018 Dec 13.

PMID: 30545255

24.

[S2k guidelines of the PEG on calculated parenteral initial treatment of bacterial diseases in adults : Focussed summary and supplementary information on antibiotic treatment of critically ill patients].

Brinkmann A, Röhr AC, Frey OR, Krüger WA, Brenner T, Richter DC, Bodmann KF, Kresken M, Grabein B.

Anaesthesist. 2018 Dec;67(12):936-949. doi: 10.1007/s00101-018-0512-8.

PMID: 30511110 Review.German.

25.

[Adequate anti-infective treatment : Importance of individual dosing and application].

Brinkmann A, Röhr AC, Köberer A, Fuchs T, Krüger WA, König C, Richter D, Weigand MA, Frey OR.

Anaesthesist. 2018 Jun;67(6):461-476. doi: 10.1007/s00101-018-0443-4.

PMID: 29766208 Review.German.

26.

Development of a dosing nomogram for continuous-infusion meropenem in critically ill patients based on a validated population pharmacokinetic model.

Minichmayr IK, Roberts JA, Frey OR, Roehr AC, Kloft C, Brinkmann A.

J Antimicrob Chemother. 2018 May 1;73(5):1330-1339. doi: 10.1093/jac/dkx526.

PMID: 29425283

27.

Linezolid in liver failure: exploring the value of the maximal liver function capacity (LiMAx) test in a pharmacokinetic pilot study.

Wicha SG, Frey OR, Roehr AC, Pratschke J, Stockmann M, Alraish R, Wuensch T, Kaffarnik M.

Int J Antimicrob Agents. 2017 Oct;50(4):557-563. doi: 10.1016/j.ijantimicag.2017.06.023. Epub 2017 Jul 12.

PMID: 28711678

28.

Population pharmacokinetics and dosing simulations of ceftazidime in critically ill patients receiving sustained low-efficiency dialysis.

König C, Braune S, Roberts JA, Nierhaus A, Steinmetz OM, Baehr M, Frey OR, Langebrake C, Kluge S.

J Antimicrob Chemother. 2017 May 1;72(5):1433-1440. doi: 10.1093/jac/dkw592.

PMID: 28175308

29.

Population pharmacokinetics of meropenem in elderly patients: dosing simulations based on renal function.

Usman M, Frey OR, Hempel G.

Eur J Clin Pharmacol. 2017 Mar;73(3):333-342. doi: 10.1007/s00228-016-2172-4. Epub 2016 Dec 13.

PMID: 27966034

30.

Cerebrospinal fluid penetration of meropenem in neurocritical care patients with proven or suspected ventriculitis: a prospective observational study.

Blassmann U, Roehr AC, Frey OR, Vetter-Kerkhoff C, Thon N, Hope W, Briegel J, Huge V.

Crit Care. 2016 Oct 24;20(1):343. doi: 10.1186/s13054-016-1523-y.

PMID: 27776537 Free PMC article.

31.

[Therapeutic drug monitoring and individual dosing of antibiotics during sepsis : Modern or just "trendy"?].

Brinkmann A, Röhr AC, Köberer A, Fuchs T, Preisenberger J, Krüger WA, Frey OR.

Med Klin Intensivmed Notfmed. 2018 Mar;113(2):82-93. doi: 10.1007/s00063-016-0213-5. Epub 2016 Sep 13.

PMID: 27624768 Review.German.

32.

Decreased Linezolid Serum Concentrations in Three Critically Ill Patients: Clinical Case Studies of a Potential Drug Interaction between Linezolid and Rifampicin.

Blassmann U, Roehr AC, Frey OR, Koeberer A, Briegel J, Huge V, Vetter-Kerkhoff C.

Pharmacology. 2016;98(1-2):51-5. doi: 10.1159/000445194. Epub 2016 Apr 6.

PMID: 27046487

33.

What is the effect of obesity on piperacillin and meropenem trough concentrations in critically ill patients?

Alobaid AS, Brinkmann A, Frey OR, Roehr AC, Luque S, Grau S, Wong G, Abdul-Aziz MH, Roberts MS, Lipman J, Roberts JA.

J Antimicrob Chemother. 2016 Mar;71(3):696-702. doi: 10.1093/jac/dkv412. Epub 2015 Dec 24.

PMID: 26702922

34.

Anti-infective drugs during continuous hemodialysis - using the bench to learn what to do at the bedside.

Roehr AC, Frey OR, Koeberer A, Fuchs T, Roberts JA, Brinkmann A.

Int J Artif Organs. 2015 Jan;38(1):17-22. doi: 10.5301/ijao.5000377. Epub 2015 Jan 23.

PMID: 25633891

35.

Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions.

Roberts JA, Abdul-Aziz MH, Lipman J, Mouton JW, Vinks AA, Felton TW, Hope WW, Farkas A, Neely MN, Schentag JJ, Drusano G, Frey OR, Theuretzbacher U, Kuti JL; International Society of Anti-Infective Pharmacology and the Pharmacokinetics and Pharmacodynamics Study Group of the European Society of Clinical Microbiology and Infectious Diseases.

Lancet Infect Dis. 2014 Jun;14(6):498-509. doi: 10.1016/S1473-3099(14)70036-2. Epub 2014 Apr 24.

PMID: 24768475 Free PMC article. Review.

36.

An international, multicentre survey of β-lactam antibiotic therapeutic drug monitoring practice in intensive care units.

Wong G, Brinkman A, Benefield RJ, Carlier M, De Waele JJ, El Helali N, Frey O, Harbarth S, Huttner A, McWhinney B, Misset B, Pea F, Preisenberger J, Roberts MS, Robertson TA, Roehr A, Sime FB, Taccone FS, Ungerer JP, Lipman J, Roberts JA.

J Antimicrob Chemother. 2014 May;69(5):1416-23. doi: 10.1093/jac/dkt523. Epub 2014 Jan 16.

PMID: 24443514